In vitro metabolism of diarylpyrazoles, a novel group of cannabinoid receptor ligands.

@article{Zhang2005InVM,
  title={In vitro metabolism of diarylpyrazoles, a novel group of cannabinoid receptor ligands.},
  author={Qiang Zhang and Peng Ma and Weiqun Wang and Richard B Cole and Guangdi Wang},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2005},
  volume={33 4},
  pages={508-17}
}
Diarylpyrazoles are a group of 1,5-diphenylpyrazole analogs of which several have been found to exhibit antagonist properties toward the cannabinoid receptors. SR141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide], the first reported antagonist, is a highly potent and selective CB1 receptor ligand that prevents or reverses CB1-mediated effects. Other analogs, such as AM251 [N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl… CONTINUE READING

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