In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients.

@article{WeillEngerer2003InVM,
  title={In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients.},
  author={S{\'e}bastien Weill-Engerer and Jean Philippe David and V{\'e}ronique Sazdovitch and Philippe Li{\`e}re and Michael Schumacher and Andr{\'e} Delacourte and Etienne Emile Baulieu and Yvette Akwa},
  journal={Brain research},
  year={2003},
  volume={969 1-2},
  pages={
          117-25
        }
}
The description of dehydroepiandrosterone (DHEA) as a neuroactive neurosteroid has raised the important question of whether the steroid itself and/or its metabolite(s) are active in the brain. Classical transformations of DHEA in brain and peripheral tissues include its conversion to testosterone and estradiol. In the human brain, the metabolism of DHEA to other metabolites is still poorly understood, particularly in aging people and Alzheimer's patients. The present study describes the in… CONTINUE READING

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