In-vitro metabolic studies of tacrolimus using precision-cut rat and human liver slices.

Abstract

The objective of this study was to investigate the in-vitro metabolism of tacrolimus in liver slices from rats and humans. [14C]Tacrolimus (2 or 20 microM) was incubated with precision-cut human and rat liver slices in 12-well plates for up to 12 h. Concentrations of tacrolimus and metabolites were determined by high-performance liquid chromatography (HPLC… (More)

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@article{Ueda1996InvitroMS, title={In-vitro metabolic studies of tacrolimus using precision-cut rat and human liver slices.}, author={Shoji Ueda and Mariana Cook and Ala M. Alak}, journal={Journal of pharmaceutical and biomedical analysis}, year={1996}, volume={15 3}, pages={349-57} }