In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4

@article{Li2011InVM,
  title={In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4},
  author={Jinghu Li and T. G{\"o}decke and S. Chen and Ayano Imai and D. Lankin and N. Farnsworth and G. Pauli and R. V. van Breemen and D. Nikolic},
  journal={Xenobiotica},
  year={2011},
  volume={41},
  pages={1021 - 1030}
}
Women who experience hot flashes as a side effect of tamoxifen (TAM) therapy often try botanical remedies such as black cohosh to alleviate these symptoms. Since pharmacological activity of TAM is dependent on the metabolic conversion into active metabolites by the action of cytochromes P450 2D6 (CYP2D6) and 3A4, the objective of this study was to evaluate whether black cohosh extracts can inhibit formation of active TAM metabolites and possibly reduce its clinical efficacy. At 50 μg/mL, a 75… Expand
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