In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4

  title={In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4},
  author={Jinghu Li and T. G{\"o}decke and S. Chen and Ayano Imai and D. Lankin and N. Farnsworth and G. Pauli and R. V. van Breemen and D. Nikolic},
  pages={1021 - 1030}
Women who experience hot flashes as a side effect of tamoxifen (TAM) therapy often try botanical remedies such as black cohosh to alleviate these symptoms. Since pharmacological activity of TAM is dependent on the metabolic conversion into active metabolites by the action of cytochromes P450 2D6 (CYP2D6) and 3A4, the objective of this study was to evaluate whether black cohosh extracts can inhibit formation of active TAM metabolites and possibly reduce its clinical efficacy. At 50 μg/mL, a 75… Expand
Inhibitory effects of Danhong Injection and its major constituents on human cytochrome P450 enzymes in vitro.
Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4
  • C. Jin, X. He, +5 authors Yaowen Fan
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in biological systems
  • 2015
Lotus leaf alkaloid fraction can strongly inhibit CYP2D6 isoenzyme activity.
Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.).
Cytochrome P450 enzyme mediated herbal drug interactions (Part 2)
Quantification of the total amount of black cohosh cycloartanoids by integration of one specific 1H NMR signal
Identification and characterization of potent CYP2D6 inhibitors in lotus leaves.
A transcriptomic analysis of black cohosh: Actein alters cholesterol biosynthesis pathways and synergizes with simvastatin.
  • L. Einbond, M. Soffritti, +5 authors A. Roter
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2018


Fukinolic acid derivatives and triterpene glycosides from black cohosh inhibit CYP isozymes, but are not cytotoxic to Hep-G2 cells in vitro.
In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.
Isolation of CYP3A4 Inhibitors from the Black Cohosh (Cimicifuga racemosa)
Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).
Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail
Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes.
Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6