In vitro mechanistic study towards a better understanding of ZnO nanoparticle toxicity.

@article{BuerkiThurnherr2013InVM,
  title={In vitro mechanistic study towards a better understanding of ZnO nanoparticle toxicity.},
  author={Tina Buerki-Thurnherr and Lisong Xiao and Liliane Diener and Osman Arslan and Cordula Hirsch and Xenia Maeder-Althaus and Kathrin Grieder and Bruno Wampfler and Sanjay Mathur and Peter Wick and Harald F Krug},
  journal={Nanotoxicology},
  year={2013},
  volume={7 4},
  pages={402-16}
}
ZnO nanoparticles (NPs) elicit significant adverse effects in various cell types, organisms and in the environment. The toxicity of nanoscale ZnO has often been ascribed to the release of zinc ions from the NPs but it is not yet understood to which extent these ions contribute to ZnO NP toxicity and what are the underlying mechanisms. Here, we take one step forward by demonstrating that ZnO-induced Jurkat cell death is largely an ionic effect involving the extracellular release of high amounts… CONTINUE READING