In vitro manipulation of mammalian preimplantation embryos can alter transcript abundance of histone variants and associated factors.

Abstract

Manipulation of mammalian embryos and gametes in vitro reduces viability. Specific causes for these reductions are still largely undetermined. Accumulating evidence suggests that survival rates and developmental competency may be reduced following disruptions in the epigenetic regulation of gene expression. Chromatin-based epigenetics can regulate the… (More)
DOI: 10.1089/cell.2011.0011

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