In vitro leishmanicidal activity of Tityus discrepans scorpion venom

@article{Borges2006InVL,
  title={In vitro leishmanicidal activity of Tityus discrepans scorpion venom},
  author={Adolfo Borges and Sylvia Silva and Huub J. M. Op den Camp and Elena Velasco and Marco {\'A}lvarez and Marcelo J.M. Alfonzo and Alicia Jorquera and Leonardo Ramon Nunes de Sousa and Olinda M Delgado},
  journal={Parasitology Research},
  year={2006},
  volume={99},
  pages={167-173}
}
Leishmania parasites are sensitive to peptides with antimicrobial and ion-channel inhibitory activity. Because scorpion venoms are rich sources of such peptides, the leishmanicidal effect of Tityus discrepans venom was investigated. A negative correlation between cell growth and venom concentration was observed for venom-treated cultures of Leishmania (L.) mexicana mexicana promastigotes; 50% growth inhibition was obtained at 0.4 μg/ml. Light microscopy showed rounded, highly vacuolated L. (L… CONTINUE READING