In vitro kinetics of coumarin 3,4-epoxidation: application to species differences in toxicity and carcinogenicity.

@article{Born2000InVK,
  title={In vitro kinetics of coumarin 3,4-epoxidation: application to species differences in toxicity and carcinogenicity.},
  author={Stephanie L Born and Douglas Caudill and Bryan J. Smith and Lois D. Lehman-McKeeman},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2000},
  volume={58 1},
  pages={23-31}
}
Coumarin, a natural product and fragrance ingredient, is a well recognized rat liver toxicant, and dietary administration at toxic dosages increased the incidence of rat cholangiocarcinomas and parenchymal liver-cell tumors in a chronic bioassay. Hepatotoxicity in rats is site- and species-specific, and is thought to result from the formation of coumarin 3,4-epoxide and its rearrangement product, o-hydroxyphenylacetaldehyde (o-HPA). The goals of the current study were to describe the in vitro… CONTINUE READING

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