In vitro kinetics of 8-methoxypsoralen penetration into human lymphoid cells.

Abstract

Extracorporeal photochemotherapy (ECPC) requires ex vivo UVA irradiation of blood lymphocytes during the time of the theoretical peak 8-methoxsalen (8-MOP) concentration. The aims of this study were to determine the mechanism of cellular uptake of 8-MOP, its possible saturation and the time needed to reach maximal concentration (Tmax) in lymphoid cells. 8… (More)

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@article{Karolak1992InVK, title={In vitro kinetics of 8-methoxypsoralen penetration into human lymphoid cells.}, author={L A Karolak and Michel Tod and A. Le{\'o}n and A M Heudes and Olivier Petitjean and Liliane Laroche}, journal={Photodermatology, photoimmunology & photomedicine}, year={1992}, volume={9 2}, pages={58-60} }