In vitro ischemia decreases histone H4K16 acetylation in neural cells.

@article{Dmitriev2015InVI,
  title={In vitro ischemia decreases histone H4K16 acetylation in neural cells.},
  author={Ruslan I Dmitriev and Dmitri B. Papkovsky},
  journal={FEBS letters},
  year={2015},
  volume={589 1},
  pages={138-44}
}
Inhibitors of histone deacetylases are frequently used against ischemia-induced injury, but the specific mechanisms of their action are poorly understood. Here, we report that following a 5-7-h oxygen-glucose deprivation (OGD) acetylation of histone H4 at residue K16 (H4K16Ac) decreases by 40-80% in both PC12 cells and primary neurons. This effect can be reverted by treatment with trichostatin A, or by supplementation with acetyl-CoA. A decrease in H4K16Ac levels can affect the expression of… CONTINUE READING
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