In vitro investigation of the liberation of fluoride ions from toothpaste compounds in a permeation model.

@article{Eggert1999InVI,
  title={In vitro investigation of the liberation of fluoride ions from toothpaste compounds in a permeation model.},
  author={Frederick C. Eggert and Reinhard H.H Neubert},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={1999},
  volume={47 2},
  pages={
          169-73
        }
}
The most important requirement for effective topical fluoride prophylaxis from toothpaste containing fluoride is that the active fluoride agent must be chemically free, and the rapid spread of the dissolved fluoride ions over the tooth surface. Abrasive compounds in the toothpastes and the brief residence time at the site of action, the oral cavity and tooth surface must not prevent the liberation. Using a two-chamber diffusion cell and an ion-selective fluoride electrode, the content of… CONTINUE READING