In vitro investigation of BK-218, a new oral and parenteral cephalosporin

@article{Szab1990InVI,
  title={In vitro investigation of BK-218, a new oral and parenteral cephalosporin},
  author={Istv{\'a}n J Szab{\'o} and Judit Barab{\'a}s and A K Tar and L{\'a}szl{\'o} Kiss and M. Y. Filep and Tim Schmidt and K{\'a}lm{\'a}n Marossy and Bela L. Toth-Martinez and Gy{\"o}rgy Barab{\'a}s and Ferenc Hern{\'a}di},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1990},
  volume={34},
  pages={349 - 354}
}
The antibacterial activity of BK-218 was similar to that of cefamandole when it was tested against several laboratory strains. The inhibiting effect of BK-218 was greater than that of cephalexin and cefoxitin on penicillin-binding proteins of Escherichia coli HB101. This result was in close correlation with the relative inhibition of radiolabeled glucosamine incorporation (greatest with BK-218) and with the lytic effect (most intensive with BK-218). BK-218 proved to be a good inhibitor for all… Expand
Antimicrobial activity of three investigational oral cephalosporins (BK-218, cefdinir, and RU29246) against Legionella.
TLDR
Three new, orally administered cephalosporins (BK-218, cefdinir, RU29246) were tested against 13 representative strains of Legionella and appear poorly suited by activity assays for Legionellosis therapy. Expand
Antibacterial activity of the investigational oral and parenteral cephalosporin BK-218
  • D. M. Johnson, R. Jones
  • Biology, Medicine
  • European Journal of Clinical Microbiology and Infectious Diseases
  • 2005
TLDR
BK-218 was active against Streptococcus pneumoniae, Haemophilus influenzae andMoraxella catarrhalis but strains resistant to penicillins had higher MICs and BK- 218 had greater activity than cefuroxime or cefaclor against oxacillin-susceptibleStaphylococcus spp. Expand
New cephalosporins in development pipelines
TLDR
One of the most commercially successful classes of human antibacterials is the cephalosporins, intially introduced in the 1960s, commanding a major market share worldwide and many in development, many seeking a niche position to gain a foothold in a mature therapy area. Expand

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