In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signals

@article{Xie1995InVI,
  title={In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signals},
  author={Heng Xie and Timothy Turner and M Wang and Raj Karan Singh and Gene P. Siegal and Alan Wells},
  journal={Clinical & Experimental Metastasis},
  year={1995},
  volume={13},
  pages={407-419}
}
Prostate carcinomas often present an autocrine stimulatory loop in which the transformed cells both express the EGF receptor (EGFR) and produce activating ligands (TGFα and EGF forms). Up-regulated EGFR signalling has been correlated with tumor progression in other human neoplasia; however, the cell behaviour which is promoted remains undefined. To determine whether an EGFR-induced response contributes to cell invasiveness, we transduced DU-145 human prostate carcinoma cells with either a full… CONTINUE READING

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