In vitro interaction between amphotericin B and azoles in Candida albicans.

@article{Vazquez1996InVI,
  title={In vitro interaction between amphotericin B and azoles in Candida albicans.},
  author={Jose Alberto Vazquez and M. Teresa Arganoza and J K Vaishampayan and Robert A. Akins},
  journal={Antimicrobial agents and chemotherapy},
  year={1996},
  volume={40 11},
  pages={2511-6}
}
The use of azole prophylaxis as a measure to prevent invasive fungal infections in high-risk patients is increasing and is now the standard of care in many institutions. Previous studies disagree on whether preexposure of Candida albicans to azoles affects their subsequent susceptibility to amphotericin B (AmB). The present in vitro study indicates that azole exposure generates a subpopulation of cells that are not affected by subsequent exposure to AmB. These cells that are phenotypically… CONTINUE READING

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