In vitro inhibitory effects of pristimerin on human liver cytochrome P450 enzymes.

@article{Hao2018InVI,
  title={In vitro inhibitory effects of pristimerin on human liver cytochrome P450 enzymes.},
  author={Xiaoyi Hao and Jianlei Yuan and Yansen Xu and Zhao Wang and Jianzhang Hou and Tao Hu},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2018},
  pages={1-7}
}
1.Pristimerin (PTM) is a biological component isolated from Chinese herbal plant Celastrus and Maytenus spp. and it possesses numerous pharmacological activities. However, whether PTM affects the activity of human liver cytochrome P450 (CYP) enzymes remains unclear. 2.In this study, the inhibitory effects of PTM on the eight human liver CYP isoforms (i.e. 1A2, 3A4, 2A6, 2E1, 2D6, 2C9, 2C19 and 2C8) were investigated in vitro using human liver microsomes (HLMs). 3.The results showed that PTM… CONTINUE READING