In vitro inhibitory effects of herbal supplements on tamoxifen and irinotecan metabolism

  title={In vitro inhibitory effects of herbal supplements on tamoxifen and irinotecan metabolism},
  author={F. Grappe and G. Nance and L. Coward and G. Gorman},
  journal={Drug Metabolism and Drug Interactions},
  pages={269 - 279}
Abstract Background: As the use of herbal supplements continues to rise throughout the world, the potential for drug-herbal interactions also increases. For chemotherapeutic prodrugs, this interaction could prevent the metabolic conversion of the prodrug to its active metabolite(s), thereby potentially resulting in subtherapeutic systemic exposure of the drug and reduced efficacy of the therapy. Methods: In this study, in vitro metabolism with human liver microsomes is used to measure the… Expand


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