In vitro inhibitory effects of Kampo medicines on metabolic reactions catalyzed by human liver microsomes.

@article{Takahashi2003InVI,
  title={In vitro inhibitory effects of Kampo medicines on metabolic reactions catalyzed by human liver microsomes.},
  author={Kiyoharu Takahashi and Etsuko Uejima and Tomohiro Morisaki and Nobuhiro Kurokawa and Junzo Azuma},
  journal={Journal of clinical pharmacy and therapeutics},
  year={2003},
  volume={28 4},
  pages={
          319-27
        }
}
BACKGROUND Although it is well known that drug-drug interactions may lead to toxicity and therapeutic failure, little is known about the incidence and consequences of herb-drug interactions in patients receiving Kampo medicines. METHODS We evaluated the frequency of the combined use of Kampo medicines and Western drugs at Osaka University Hospital, and investigated the effects of these formulae on the metabolic activity of different cytochrome P450 (CYP) isoforms using pooled microsomes… CONTINUE READING

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