In vitro inhibitory effects of J-113397 on nociceptin/orphanin FQ-stimulated.

@article{Ichikawa2001InVI,
  title={In vitro inhibitory effects of J-113397 on nociceptin/orphanin FQ-stimulated.},
  author={Daisuke Ichikawa and Satoshi Ozaki and Takeshi Azuma and Hirohide Nambu and Hiroshi Kawamoto and Yoshikazu Iwasawa and Hiroshi Takeshima and Hisashi Ohta},
  journal={Neuroreport},
  year={2001},
  volume={12 8},
  pages={1757-61}
}
J-113397 (1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one) is a recently developed antagonist of the opioid receptor-like 1 (ORL1) receptor. We compared the in vitro functional profile J-113397 on [35S]guanosine 5'-O-(gamma-thio)triphosphate (GTPgammaS) binding to mouse brain with that of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 and naloxone benzoylhydrazone (NalBzoH). J-113397 antagonized nociceptin/orphanin FQ-stimulated [35S]GTPgammaS… CONTINUE READING