In vitro inhibition of simvastatin metabolism in rat and human liver by naringenin.

@article{Ubeaud1999InVI,
  title={In vitro inhibition of simvastatin metabolism in rat and human liver by naringenin.},
  author={Genevi{\`e}ve Ubeaud and J Hagenbach and S. Vandenschrieck and Louis Jung and J. C. Koffel},
  journal={Life sciences},
  year={1999},
  volume={65 13},
  pages={1403-12}
}
We demonstrated that naringenin (NRG), the aglycon form of naringin present in grapefruit juice inhibits in vitro the metabolism of simvastatin (SV), a HMG-CoA reductase inhibitor. SV undergoes an important first pass metabolism and this is thought to be partly responsible for its low bioavailability after oral administration. SV is a prodrug that requires metabolic activation through hydrolysis by esterases. In addition, SV is a substrate for cytochrome P450 enzymes. NRG, a potent inhibitor of… CONTINUE READING
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