In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs

  title={In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs},
  author={J. Mccook and P. Dorogi and D. Vasily and Dustin R. Cefalo},
  journal={Clinical, Cosmetic and Investigational Dermatology},
  pages={443 - 448}
Background Inhibitors of hyaluronidase are potent agents that maintain hyaluronic acid homeostasis and may serve as anti-aging, anti-inflammatory, and anti-microbial agents. Sodium copper chlorophyllin complex is being used therapeutically as a component in anti-aging cosmeceuticals, and has been shown to have anti-hyaluronidase activity. In this study we evaluated various commercial lots of sodium copper chlorophyllin complex to identify the primary small molecule constituents, and to test… Expand
Inhibitory activity of Podospermum canum and its active components on collagenase, elastase and hyaluronidase enzymes.
Investigation of in vitro inhibitory effects of the extract prepared from the aerial parts of Podospermum canum (Asteraceae) on hyaluronidase, collagenase, and elastase enzymes using a bioassay-guided fractionation revealed potent enzyme inhibitory activities of apigenin 7-O-β-glucoside, luteolin 7-Dicaffeoylquinic acid methyl ester, and isoorientin showed potent inhibition. Expand
In silico evaluation of antimicrobial, antihyaluronidase and bioavailability parameters of rosmarinic acid in Perilla frutescens leaf extracts
The present study reports ultrasound-assisted extraction of rosmarinic acid extract using the leaves of Perilla frutescens L. by using ethanol solvent. P. frutescens rosmarinic acid extract (PF-RAE)Expand
Bioassay-Guided Isolation, Metabolic Profiling, and Docking Studies of Hyaluronidase Inhibitors from Ravenala madagascariensis
The results highlight Ravenala madagascariensis and its flavonoids as promising hyaluronidase inhibitors in natural cosmetology preparations for skin care. Expand
Ability of sodium copper chlorophyllin complex to repair photoaged skin by stimulation of biomarkers in human extracellular matrix
The results of this human biopsy study suggest that both retinoids and sodium copper chlorophyllin complex have beneficial effects on biomarkers of photoaged skin. Expand
In vitro anti‐inflammatory and skin protective properties of extract comprising ceramides from de‐oiled rice bran
De-oiled rice bran is a byproduct of rice processing industries and rich in lipids, carbohydrates, proteins, and fibers. Although rich in nutrients, it is unfit for human consumption and used asExpand
Chlorophylls and their Derivatives Used in Food Industry and Medicine.
A comprehensive overview of the health benefits and potential medicinal applications of these pigments and the future directions of research in these fields are provided. Expand
Eleutherococcus Species Cultivated in Europe: A New Source of Compounds with Antiacetylcholinesterase, Antihyaluronidase, Anti-DPPH, and Cytotoxic Activities
A phytochemical composition and activity of the Eleutherococcus species, cultivated in Poland, are still under research; however, on the basis of the results obtained it may be concluded that they may become a source of phytochemicals and be useful for Europe's citizens. Expand
Cosmetic potentials of Prunus domestica L. leaves.
The plum leaves were found to possess promising anti-aging activities by their capacity to inhibit 1,1-diphenyl-2-picrylhydrazyl (DPPH), elastase, hyaluronidase and lipoxygenase. Expand
Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway
Seaweed fulvescens treatment inhibited the development of AD symptoms, compared to that in the control group, as evidenced from the improved dorsal skin lesion, reduced thickness and infiltration of inflammatory cells and smaller lymph nodes, and reduced levels of proinflammatory cytokines. Expand
Comparative proteomic analysis of female and male venoms from the Mexican scorpion Centruroides limpidus: Novel components found
The presence of metalloproteinases (proteolytic enzymes), hyaluronidases and phosphatases were experimentally determined and shown to be present in both venom samples and should help further work aimed at fully identification of the structure and function of venom components form C. limpidus male and female scorpions. Expand


l-Ascorbic Acid 6-Hexadecanoate, a Potent Hyaluronidase Inhibitor
It is shown that l-ascorbic acid 6-hexadecanoate (VCPal) is a potent inhibitor of both streptococcal and bovine testicular hyaluronidase (BTH), and the x-ray structure of the SpnHL-Vcpal complex is determined and the hypothesis that additional hydrophobic interactions with Phe-343, His-399, and Thr-400 in the active site led to increased inhibition is confirmed. Expand
Inhibitors of the hyaluronidases.
  • K. Mio, R. Stern
  • Chemistry, Medicine
  • Matrix biology : journal of the International Society for Matrix Biology
  • 2002
This molecule, found in the hyaluronan-rich cumulus mass surrounding mammalian ova and the pericellular coat of fibroblasts and mesothelial cells, may function to stabilize such matrices by protecting against hyaluranidase degradation. Expand
Hyaluronidase and collagenase inhibitory activities of the herbal formulation Triphala guggulu
This study provides the first in vitro preclinical evidence of the chondroprotective properties of TG, and is the first report to show that the T2 component of Triphala (T. chebula) is a highly potent hyaluronidase and collagenase inhibitor. Expand
Hyaluronidase inhibitors: a biological and therapeutic perspective.
An integrated update as of 2008 is expected to provide an integrated update on the HAase inhibitors and their possible role as therapeutics in the management of a wide range of pathological conditions. Expand
Anti-Ageing Ability of Terminalia Species with Special Reference to Hyaluronidase , Elastase Inhibition and Collagen Synthesis In Vitro
Hydroalcoholic extracts prepared from bark of Terminalia arjuna and dried fruit rinds of Terminalia chebula were examined for their effects on enzyme Hyaluronidase and Elastase activity. The extractsExpand
Copper chlorophyllin: A food colorant with bioactive properties?
Abstract Copper chlorophyllin (Cu-Chl) is a chlorophyll-derived food colorant, commercially available as a complex mixture of different chlorin molecules. Several studies have reported greatExpand
The hyaluronidase inhibitor of human blood.
Evidence was presented casting doubt on the enzyme nature of the substance in blood which interferes with hyaluronidase activity and it was concluded that there exists a complex system consisting of at least two different antinvasins and a substance accompanying hyaluronic acid which was named “proinvasin I”. Expand
Collagen Fragments Inhibit Hyaluronan Synthesis in Skin Fibroblasts in Response to Ultraviolet B (UVB)
Data suggest that CF activate αvβ3-integrins and in turn inhibit Rho kinase (ROCK) signaling and nuclear translocation of phosphoERK, resulting in reduced HAS2 expression. Expand
Age-dependent changes of hyaluronan in human skin.
  • L. Meyer, R. Stern
  • Chemistry, Medicine
  • The Journal of investigative dermatology
  • 1994
It is concluded that neither the concentration nor polymer size of hyaluronan changes as a function of age, however, enhanced association with tissue occurs, presumably through hy aluronan-binding proteins and alterations in the histolocalization of hyAluronan. Expand
Heparinic effects of cupridihydroporphyrins (water-soluble chlorophyllins).
The medicinal, water-soluble chlorophyllin Chloresium and some of its derivatives are shown to be heparin-like substances in that they act as an antithrombic in the blood coagulation mechanism andExpand