• Chemistry, Biology, Medicine
  • Published in
    Journal of agricultural and…
    2005
  • DOI:10.1021/jf048497+

In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes.

@article{DellAgli2005InVI,
  title={In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes.},
  author={Mario Dell'Agli and Germana V. Galli and Urska Vrhovsek and Fulvio Mattivi and Enrica Bosisio},
  journal={Journal of agricultural and food chemistry},
  year={2005},
  volume={53 6},
  pages={
          1960-5
        }
}
A moderate consumption of red wine may reduce the risk of cardiovascular diseases via wine-derived phenolic compounds. A variety of biological mechanisms have been proposed for wine-derived phenolic compounds including nitric oxide-mediated vasorelaxation. This study examined whether the vasodilating effect of wine-derived phenolic compounds was associated with the inhibition of phosphodiesterases (PDEs) and, in particular, PDE5. For this purpose, human recombinant PDE5A1 isoform was prepared… CONTINUE READING

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