In vitro inhibition of glucose phosphorylation by an aldose-reductase inhibitor (Tolrestat) in some non-insulin-sensitive rabbit tissues.

@article{Iannello1999InVI,
  title={In vitro inhibition of glucose phosphorylation by an aldose-reductase inhibitor (Tolrestat) in some non-insulin-sensitive rabbit tissues.},
  author={S. Iannello and A. Cavaleri and M. Camuto and F. Belfiore},
  journal={Journal of diabetes and its complications},
  year={1999},
  volume={13 2},
  pages={
          68-73
        }
}
  • S. Iannello, A. Cavaleri, +1 author F. Belfiore
  • Published 1999
  • Biology, Medicine
  • Journal of diabetes and its complications
  • We have previously demonstrated that in some non-insulin-sensitive tissues (capillaries of eel swimbladder Rete mirabile, and rabbit eye choroidocapillary lamina, optic nerve, retina, and lens) glucose phosphorylation increases with the increase in the concentration of glucose, a characteristic relevant to the hyperglycemia of diabetes. In the present research we demonstrate an effect of the aldose reductase inhibitor, Tolrestat, on the glucose-phosphorylating activity of rabbit lens and optic… CONTINUE READING
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