In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products.

@article{Hellum2008InVI,
  title={In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products.},
  author={Bent H{\aa}vard Hellum and Odd Georg Nilsen},
  journal={Basic & clinical pharmacology & toxicology},
  year={2008},
  volume={102 5},
  pages={
          466-75
        }
}
  • Bent Håvard Hellum, Odd Georg Nilsen
  • Published 2008
  • Medicine, Biology
  • Basic & clinical pharmacology & toxicology
  • Extracts of six commonly used commercially available herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut were investigated for their in vitro inhibitory potential of CYP3A4 mediated metabolism and P-glycoprotein efflux transport activity. C-DNA baculovirus expressed CYP3A4 and Caco-2 cells were used. Ketoconazole and verapamil were applied as positive control inhibitors, respectively. A validated high-performance liquid… CONTINUE READING

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    Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein

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