In vitro infection of human primary adipose cells with HIV-1: a reassessment.

@article{Munier2003InVI,
  title={In vitro infection of human primary adipose cells with HIV-1: a reassessment.},
  author={Sandie Munier and Alejandra Borjabad and Morgane Lemaire and Virginie Mariot and Uriel Hazan},
  journal={AIDS},
  year={2003},
  volume={17 17},
  pages={2537-9}
}
We reassessed the infection ability of human primary preadipocytes. The use of X4, R5 or VSV-G-pseudotyped viral particles indicated that viral entry is the limiting step. However, transfection with HIV-1 receptors restored efficient infection. Analyses of CD4, CXCR4 and CCR5 expression on preadipocytes and adipocytes revealed that receptor co-expression levels did not permit HIV-1 entry into adipose cells from all biopsies tested. We concluded that adipose tissue cannot be infected with HIV-1… CONTINUE READING

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