In vitro infection of human dendritic cells by Aspergillus fumigatus conidia triggers the secretion of chemokines for neutrophil and Th1 lymphocyte recruitment.

@article{Gafa2007InVI,
  title={In vitro infection of human dendritic cells by Aspergillus fumigatus conidia triggers the secretion of chemokines for neutrophil and Th1 lymphocyte recruitment.},
  author={Val{\'e}rie Gafa and Maria Elena Remoli and Elena Giacomini and Maria Cristina Gagliardi and Roberto Lande and Martina Severa and Ren{\'e}e Grillot and Eliana M Coccia},
  journal={Microbes and infection},
  year={2007},
  volume={9 8},
  pages={971-80}
}
Given the role played by chemokines in the selective homing of immune cells, we sought to characterize the profile of chemokines produced by human dendritic cells (DC) following in vitro Aspergillus fumigatus infection and their ability to recruit cells involved in the antifungal defense. At the onset of A. fumigatus infection, DC released elevated amounts of CXCL8 that promote the migration of polymorphonuclear cells (PMN). Moreover, soluble factors released from A. fumigatus-infected DC… CONTINUE READING
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