In vitro induction of swine peripheral blood monocyte proliferation by the fibroblast-derived murine hematopoietic growth factor CSF-1.

@article{Genovesi1989InVI,
  title={In vitro induction of swine peripheral blood monocyte proliferation by the fibroblast-derived murine hematopoietic growth factor CSF-1.},
  author={Eugene V Genovesi and Richard C. Knudsen and DataTh. Gerstner and D M Card and Carlos Jos{\'e} Vieira Martins and Julio C{\'e}sar Quintero and Terry C. Whyard},
  journal={Veterinary immunology and immunopathology},
  year={1989},
  volume={23 3-4},
  pages={223-44}
}
The addition of conditioned medium from murine L929 fibroblasts (MGF) to cultures of swine peripheral blood mononuclear cells (MNL) resulted in growth of cells of macrophage/monocyte lineage (MO). Glass-adherent swine MNL, shown to be greater than 95% phagocytic MO, grew in the presence of MGF, whereas swine blood granulocytes and lymphocytes were not MGF-responsive. Primary and secondary MO growth were directly dependent on MGF presence and concentration. MGF-stimulated MO synthesized DNA, as… CONTINUE READING
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