In vitro induction of drug monooxygenase activity by phenobarbital in the isolated mouse jejunum

Incubation of the isolated mouse jejunum with with 5×10−4 M phenobarbital results in a 2–3 fold increase in the O-deethylation activity for 7-ethoxycoumarin based on the total protein content of the mucosa cell homogenate. The incorporation of 14C-leucine into the mucosa cell proteins is about doubled under the influence of phenobarbital and can be… CONTINUE READING