In vitro induction of alkaline phosphatase levels predicts in vivo bone forming capacity of human bone marrow stromal cells.

@article{Prins2014InVI,
  title={In vitro induction of alkaline phosphatase levels predicts in vivo bone forming capacity of human bone marrow stromal cells.},
  author={H A B Prins and Arie Koen Braat and Debby Gawlitta and Wouter J. A. Dhert and David A. Egan and Estel Tijssen-Slump and Huipin Yuan and Paul James Coffer and H. B. Rozemuller and Anton C. M. Martens},
  journal={Stem cell research},
  year={2014},
  volume={12 2},
  pages={
          428-40
        }
}
One of the applications of bone marrow stromal cells (BMSCs) that are produced by ex vivo expansion is for use in in vivo bone tissue engineering. Cultured stromal cells are a mixture of cells at different stages of commitment and expansion capability, leading to a heterogeneous cell population that each time can differ in the potential to form in vivo bone. A parameter that predicts for in vivo bone forming capacity is thus far lacking. We employed single colony-derived BMSC cultures to… CONTINUE READING
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