In vitro-in vivo correlation for low-clearance compounds using hepatocyte relay method.

Abstract

In vitro-in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support high-confidence prediction of human pharmacokinetics for low-clearance compounds. Good IVIVC of intrinsic clearance was observed for most of the compounds, with predicted values within 2-fold of the… (More)
DOI: 10.1124/dmd.113.053322

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