In vitro immunization with a recombinant antigen carrying the HIV-1 RT248-262 determinant inserted at different locations results in altered TCRVB region usage.

Abstract

Immunodominance or cripticity of a peptide-borne determinant may be influenced by the protein context in which the epitope is embedded. In this frame, we previously showed that certain human T cell clones, derived from different donors, may differentially recognize the RT248-262 helper determinant depending on whether it is provided to the presenting cells… (More)

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@article{Prisco1999InVI, title={In vitro immunization with a recombinant antigen carrying the HIV-1 RT248-262 determinant inserted at different locations results in altered TCRVB region usage.}, author={Anthony R. Prisco and Giuliano Bonomi and Federica Moschella and Maria Neve Ombra and Piergiuseppe de Berardinis and J. L. Guardiola}, journal={Human immunology}, year={1999}, volume={60 9}, pages={755-63} }