In vitro identification of two adherence factors required for in vivo virulence of Pseudomonas fluorescens.

@article{Pimenta2003InVI,
  title={In vitro identification of two adherence factors required for in vivo virulence of Pseudomonas fluorescens.},
  author={Andr{\'e}a de Lima Pimenta and Patrick Di Martino and Emmanuel Le Bouder and Christian Hulen and Mark A Blight},
  journal={Microbes and infection},
  year={2003},
  volume={5 13},
  pages={1177-87}
}
By enriching a random transposon insertion bank of Pseudomonas fluorescens for mutants affected in their adherence to the human extracellular matrix protein fibronectin, we isolated 23 adherence minus mutants. Mutants showed a defect in their ability to develop a biofilm on an abiotic surface and were impaired for virulence when tested in an in vivo virulence model in the fruit fly, Drosophila melanogaster. Molecular characterisation of these mutants showed that the transposon insertions… CONTINUE READING
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