In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine

  title={In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine},
  author={Jiang Luo and S. Vashishtha and E. Hawes and G. Mckay and K. Midha and J. Fang},
  journal={Biopharmaceutics & Drug Disposition},
  • Jiang Luo, S. Vashishtha, +3 authors J. Fang
  • Published 2011
  • Chemistry, Medicine
  • Biopharmaceutics & Drug Disposition
  • In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) enzymes responsible for the oxidative metabolism of loxapine to 8‐hydroxyloxapine, 7‐hydroxyloxapine, N‐desmethylloxapine (amoxapine) and loxapine N‐oxide. These studies included use of cDNA‐expressed enzymes, correlation analysis with 12 phenotyped human liver microsomal samples, and use of selective inhibitors of cytochrome P450s. The resultant data indicated that loxapine was mainly metabolized by human liver… CONTINUE READING
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