In vitro hypoxia induces expression of the NR2C subunit of the NMDA receptor in rat cortex and hippocampus.

@article{PerezVelazquez1994InVH,
  title={In vitro hypoxia induces expression of the NR2C subunit of the NMDA receptor in rat cortex and hippocampus.},
  author={Jose L. Perez-Velazquez and Lu Zhang},
  journal={Journal of neurochemistry},
  year={1994},
  volume={63 3},
  pages={1171-3}
}
In mammalian brain, ischemic injury could be mediated by delayed glutamate neurotoxicity. We have studied the possibility of altered genetic expression of quiescent NMDA receptor subunits in an in vitro model of hypoxia-hypoglycemia, using the reverse transcription-polymerase chain reaction technique. It was found that mRNA corresponding to the NR2C subunit… CONTINUE READING