In vitro hyperresponsiveness to tumor necrosis factor-alpha contributes to adipokine dysregulation in omental adipocytes of obese subjects.

@article{Maury2009InVH,
  title={In vitro hyperresponsiveness to tumor necrosis factor-alpha contributes to adipokine dysregulation in omental adipocytes of obese subjects.},
  author={El{\'e}onore Maury and Laurence No{\"e}l and R. Detry and Sonia M. Brichard},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 4},
  pages={1393-400}
}
CONTEXT In obesity, adipocyte hypertrophy and macrophage infiltration lead to overproduction of proinflammatory adipokines, which play a crucial role in the metabolic syndrome. The molecular mechanisms underlying this overproduction are still unsettled. The role of TNF-alpha also remains controversial in human obesity. OBJECTIVE We revisited the… CONTINUE READING