In vitro human cytotoxic T cell responses against influenza A virus can be induced and selected by synthetic peptides.

@article{Martinon1990InVH,
  title={In vitro human cytotoxic T cell responses against influenza A virus can be induced and selected by synthetic peptides.},
  author={F. Martinon and Elisabeth Gomard and Claude Hannoun and Julie Levy},
  journal={European journal of immunology},
  year={1990},
  volume={20 10},
  pages={
          2171-6
        }
}
Studies on human anti-influenza cytolytic activities have demonstrated that cytotoxic T lymphocytes (CTL) from HLA-B37 individuals react preferentially with the peptide corresponding to residues 335-349 of the nucleoprotein, whereas CTL from HLA-A2 donors recognize peptide 57-68 from the viral matrix as a dominant epitope. We studied the secondary CTL response, obtained from peripheral blood mononuclear cells, of an HLA-A2+,B37+ individual stimulated either by infectious virus or by synthetic… CONTINUE READING

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