In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment.

@article{Russell2010InVH,
  title={In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment.},
  author={Katie C. Russell and Donald G Phinney and Michelle R. Lacey and Bonnie L. Barrilleaux and Kristin E Meyertholen and Kim C O'connor},
  journal={Stem cells},
  year={2010},
  volume={28 4},
  pages={788-98}
}
In regenerative medicine, bone marrow is a promising source of mesenchymal stem cells (MSCs) for a broad range of cellular therapies. This research addresses a basic prerequisite to realize the therapeutic potential of MSCs by developing a novel high-capacity assay to quantify the clonal heterogeneity in potency that is inherent to MSC preparations. The assay utilizes a 96-well format to (1) classify MSCs according to colony-forming efficiency as a measure of proliferation capacity and… CONTINUE READING

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