In vitro hepatotoxicity of the cyanobacterial alkaloid cylindrospermopsin and related synthetic analogues.

@article{Runnegar2002InVH,
  title={In vitro hepatotoxicity of the cyanobacterial alkaloid cylindrospermopsin and related synthetic analogues.},
  author={Maria T. C. Runnegar and Chaoyu Xie and Barry B. Snider and G. Ansley Wallace and Steven M Weinreb and John Kuhlenkamp},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2002},
  volume={67 1},
  pages={81-7}
}
Cylindrospermopsin (CY), a sulfate ester of a tricyclic guanidine substituted with a hydroxymethyluracil, is a cyanobacterial toxin of increasing environmental import as it frequently occurs in drinking water reservoirs. As a toxin, CY mainly targets the liver but also involves other organs. In hepatocytes CY inhibits the synthesis of protein and of glutathione, leading to cell death. The total chemical synthesis of CY has recently been reported (Xie et al., 2000, J. Am. Chem. Soc. 22, 5017… CONTINUE READING