In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3.

@article{Yanni2010InVH,
  title={In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3.},
  author={Souzan B. Yanni and Pieter Annaert and Patrick F Augustijns and Joseph G. Ibrahim and Daniel Kelly Benjamin and Dhiren R. Thakker},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2010},
  volume={38 1},
  pages={25-31}
}
Voriconazole is a broad spectrum antifungal agent for treating life-threatening fungal infections. Its clearance is approximately 3-fold higher in children compared with adults. Voriconazole is cleared predominantly via hepatic metabolism in adults, mainly by CYP3A4, CYP2C19, and flavin-containing monooxygenase 3 (FMO3). In vitro metabolism of voriconazole by liver microsomes prepared from pediatric and adult tissues (n = 6/group) mirrored the in vivo clearance differences in children versus… CONTINUE READING
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