In vitro hematotoxicity of Aplidine on human bone marrow and cord blood progenitor cells.

  title={In vitro hematotoxicity of Aplidine on human bone marrow and cord blood progenitor cells.},
  author={Susana Guzm{\'a}n G{\'o}mez and Glynn Thomas Faircloth and Luis Lopez-Lazaro and Jos{\'e} Mar{\'i}a Jimeno and Juan Antonio Bueren and Beatriz Albella},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  volume={15 4-5},
  • S. Gómez, G. Faircloth, +3 authors B. Albella
  • Published 2001
  • Biology, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
Aplidine is a cyclic depsipeptide that was isolated from a Mediterranean marine tunicate, Aplidium albicans. In experimental animals, Aplidine mediated an in vivo inhibitory effect in a number of tumor cell types. In humans, Aplidine is currently used in phase I clinical trials. Aiming to predict the hematotoxicity of Aplidine in humans, samples from human bone marrow (BM) and cord blood (CB) were exposed in vitro to increasing concentrations of the drug and then assayed for the clonogenic… Expand
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