In vitro genotoxicity of danthron and its potential mechanism.

@article{Zhang2011InVG,
  title={In vitro genotoxicity of danthron and its potential mechanism.},
  author={Zhaohui Zhang and Juanlin Fu and Biyun Yao and Xiaolin Zhang and Peng Zhao and Zong-can Zhou},
  journal={Mutation research},
  year={2011},
  volume={722 1},
  pages={
          39-43
        }
}
To ascertain the in vitro genotoxicity of danthron and its potential mechanism of action, we performed an Ames test, a cytokinesis-block micronucleus assay and a comet assay in Balb/c 3T3 cells. The Ames test revealed that danthron was mutagenic only toward Salmonella typhimurium strain TA102 in the presence of an exogenous metabolic activation system (S9 mix). Danthron (25, 50 and 100μg/ml) increased the frequencies of micronuclear cells with or without S9 mix, and the comet length, tail… 
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References

SHOWING 1-10 OF 21 REFERENCES
Characterization of the genotoxicity of anthraquinones in mammalian cells.
TLDR
The idea that inhibition of the catalytic activity of topoisomerase II contributes to anthraquinone-induced genotoxicity and mutagenicity is supported.
Genotoxicity of the laxative drug components emodin, aloe-emodin and danthron in mammalian cells: topoisomerase II mediated?
TLDR
1,8-Dihydroxyanthraquinones are under debate as plant-derived carcinogens that are found in laxatives, food colors, and possibly vegetables, and given clearcut evidence of their genotoxic activity, further research on the human cancer risk of these compounds may be warranted.
Mutagenicity of substituted anthraquinones in the Ames/Salmonella microsome system.
TLDR
The results on structure-mutagenic activity relationships suggest that the 6-methyl group plays an important role in the mutagenicActivity after metabolic activation of substituted anthraquinones and dimers.
Report from the In Vitro Micronucleus Assay Working Group.
At the Washington International Workshop on Genotoxicity Test Procedures (March 25-26, 1999), the current methodologies and data for the in vitro micronucleus test were reviewed. From this,
Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing
TLDR
The expert panel reached a consensus that the optimal version of the Comet assay for identifying agents with genotoxic activity was the alkaline (pH > 13) versions of the assay developed by Singh et al.
Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinones
TLDR
Of the anthraquinone compounds tested, only 1,2-dihydroxyanthraquin one (alizarin) exerted an uncoupling and inhibitory effect on mitochondrial respiration, indicating their genotoxic activity.
Role of quinones in toxicology.
TLDR
The evidence strongly suggests that the numerous mechanisms of quinone toxicity can be correlated with the known pathology of the parent compound(s), including benzene, polycyclic aromatic hydrocarbons, estrogens, and catecholamines.
Comparison of the sensitivities of Salmonella typhimurium strains TA102 and TA2638A to 16 mutagens.
TLDR
It is concluded that strain TA2638a should be considered as an alternative to TA102 and included, as well as the two E.coli strains, in the set of bacterial strains used in the standard test battery for mutagenicity testing.
The role of NAD(P)H oxidoreductase (DT-Diaphorase) in the bioactivation of quinone-containing antitumor agents: a review.
  • P. Gutiérrez
  • Chemistry, Medicine
    Free radical biology & medicine
  • 2000
TLDR
This review focuses on the two electron enzymatic reduction/activation of quinone-containing anticancer agents by DT Diaphorase (DTD), which has become important in oncopharmacology because its activity varies with tissues and it has been found to be elevated in tumors.
Immunoperoxidase detection of 8-hydroxydeoxyguanosine in aflatoxin B1-treated rat liver and human oral mucosal cells.
TLDR
The immunoperoxidase method, requiring a small number of cells and eliminating the need for isolation of DNA, will be useful for evaluation of oxidative damage in a wide range of biological samples.
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