In vitro genotoxicity of danthron and its potential mechanism.

  title={In vitro genotoxicity of danthron and its potential mechanism.},
  author={Zhaohui Zhang and Juanlin Fu and Biyun Yao and Xiaolin Zhang and Peng Zhao and Zong-can Zhou},
  journal={Mutation research},
  volume={722 1},
To ascertain the in vitro genotoxicity of danthron and its potential mechanism of action, we performed an Ames test, a cytokinesis-block micronucleus assay and a comet assay in Balb/c 3T3 cells. The Ames test revealed that danthron was mutagenic only toward Salmonella typhimurium strain TA102 in the presence of an exogenous metabolic activation system (S9 mix). Danthron (25, 50 and 100μg/ml) increased the frequencies of micronuclear cells with or without S9 mix, and the comet length, tail… 
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