In vitro generation of osteochondral differentiation of human marrow mesenchymal stem cells in novel collagen-hydroxyapatite layered scaffolds.

@article{Zhou2011InVG,
  title={In vitro generation of osteochondral differentiation of human marrow mesenchymal stem cells in novel collagen-hydroxyapatite layered scaffolds.},
  author={Jiaan Zhou and Caixia Xu and Gang Wu and Xiaodong Cao and Liangming Zhang and Zhichen Zhai and Zhiwen Zheng and Xiaofeng Chen and Yingjun Wang},
  journal={Acta biomaterialia},
  year={2011},
  volume={7 11},
  pages={3999-4006}
}
Integrated, layered osteochondral (OC) composite materials and/or engineered OC grafts are considered as promising strategies for the treatment of OC damage. A novel biomimetic collagen-hydroxyapatite (COL-HA) OC scaffold with different integrated layers has been generated by freeze-drying. The capacity of the upper COL layer and the lower COL/HA layer to promote the growth and differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes and osteoblasts respectively was evaluated… CONTINUE READING

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