In vitro generation of organophosphate resistant boophilus microplus (Acari: Ixodidae) cell lines.

@article{CossoBayugar2002InVG,
  title={In vitro generation of organophosphate resistant boophilus microplus (Acari: Ixodidae) cell lines.},
  author={Raquel Coss{\'i}o-Bayugar and Gale Wagner and Patricia J. Holman},
  journal={Journal of medical entomology},
  year={2002},
  volume={39 2},
  pages={278-84}
}
Three organophosphate resistant Boophilus microplus Canestrini cell lines were generated by exposing B. microplus VIII-SCC cell line to incrementally increased toxic concentrations of the acaricide coumaphos. The development of resistance was evidenced by LC50 values elevated over those of control cells. The resistant cell lines selected in higher concentrations of organophosphate, designated C44 and C54, also had significantly slower duplication rates than a resistant cell line selected in… CONTINUE READING