In vitro generation of mature dopamine neurons by decreasing and delaying the expression of exogenous Nurr1.

@article{Park2012InVG,
  title={In vitro generation of mature dopamine neurons by decreasing and delaying the expression of exogenous Nurr1.},
  author={Chang-Hwan Park and Mi-sun Lim and Yong-Hee Rhee and Sang-Hoon Yi and Boe-Kyoung Kim and Jae-won Shim and Yong Ho Kim and Sung Jun Jung and Sang-Hun Lee},
  journal={Development},
  year={2012},
  volume={139 13},
  pages={
          2447-51
        }
}
Neural stem/progenitor cell (NSC/NPC) cultures can be a source of dopamine (DA) neurons for experimental and transplantation purposes. Nurr1, a steroid receptor transcription factor, can overcome the limitations associated with differentiation of cultured NPCs into DA neurons. However, forced Nurr1 expression in NPC cultures generates non-neuronal and/or immature DA cells. We show here that the Nurr1 level and period of expression crucially affect the differentiation and maturation of Nurr1… CONTINUE READING
4
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Cell Surface Antigen Display for Neuronal Differentiation-Specific Tracking

Sang Chul Kim, Eun-Hye Lee, +6 authors Chang-Hwan Park
  • Biomolecules & therapeutics
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

Efficient Generation of Dopamine Neurons by Synthetic Transcription Factor mRNAs.

  • Molecular therapy : the journal of the American Society of Gene Therapy
  • 2017
VIEW 2 EXCERPTS
CITES METHODS

Insulin concentration is critical in culturing human neural stem cells and neurons

Y-H Rhee, Moon Hyung Choi, +7 authors S-H Lee
  • Cell Death and Disease
  • 2013
VIEW 1 EXCERPT
CITES METHODS

References

Publications referenced by this paper.
SHOWING 1-10 OF 20 REFERENCES

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2009
VIEW 1 EXCERPT

Acquisition of in vitro and in vivo functionality of Nurr1-induced dopamine neurons.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2006

Transcriptional control of midbrain dopaminergic neuron development

S. L. Ang
  • Development
  • 2006
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…