In vitro generation of human cytotoxic T lymphocytes specific for peptides derived from prostate-specific antigen.

@article{Correale1997InVG,
  title={In vitro generation of human cytotoxic T lymphocytes specific for peptides derived from prostate-specific antigen.},
  author={Pierpaolo Correale and Konstantin Walmsley and Carol A. Nieroda and Sam Zaremba and M. Z. Zhu and Jeffrey Schlom and Kwong Yok Tsang},
  journal={Journal of the National Cancer Institute},
  year={1997},
  volume={89 4},
  pages={293-300}
}
BACKGROUND Protein antigens are presented to cytotoxic T lymphocytes as small peptides (approximately 9-10 amino acids long) bound to class I molecules of the major histocompatibility complex. The identification of tumor-associated antigens and specific peptide epitopes (i.e., antigenic determinants) may be useful in the development of anticancer vaccines. The generation of a cytotoxic T-cell response to one peptide epitope (amino acids 146-154) of human prostate-specific antigen (PSA) has been… CONTINUE READING
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