In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity.

@article{Messmann2015InVM,
  title={In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity.},
  author={Joanna J Messmann and Tanja Reisser and Frank Leithaeuser and Manfred B Lutz and Klaus-Michael Debatin and Gudrun Strauss},
  journal={Blood},
  year={2015},
  volume={126 9},
  pages={1138-48}
}
Myeloid-derived suppressor cells (MDSCs) inhibit T-cell expansion and functions by versatile mechanisms such as nutrient depletion, nitrosylation, or apoptosis. Since graft-versus-host disease (GVHD) is characterized by the expansion of donor-derived T cells destroying recipient tissue, we analyzed whether MDSCs can be used for GVHD prevention in murine allogeneic bone marrow transplantation models. Transplantation of MDSCs, generated from bone marrow cells by granulocyte-macrophage colony… CONTINUE READING
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