In vitro gene delivery to hepatocytes with galactosylated polyethylenimine.

@article{Zanta1997InVG,
  title={In vitro gene delivery to hepatocytes with galactosylated polyethylenimine.},
  author={M A Zanta and O Boussif and Abdennaji Adib and J. P. Behr},
  journal={Bioconjugate chemistry},
  year={1997},
  volume={8 6},
  pages={839-44}
}
A hepatocyte-directed vector has been developed; it includes several key features thought to favor in vivo gene delivery to the liver: electrostatically neutral particles which avoid nonspecific binding to other cells, to the extracellular matrix, and to complement proteins; asialoglycoprotein receptor-mediated endocytosis which may address the complexes to the perinuclear region; and polyethylenimine (PEI)-mediated endosome buffering and swelling as an escape mechanism to the cytoplasm. This… CONTINUE READING