In vitro gene delivery by degraded polyamidoamine dendrimers.

  title={In vitro gene delivery by degraded polyamidoamine dendrimers.},
  author={M. X. Tang and Carl T. Redemann and Francis C. Szoka},
  journal={Bioconjugate chemistry},
  volume={7 6},
Transfection of cultured cells has been reported using complexes between DNA and spherical cationic polyamidoamine polymers (Starburst dendrimers) that consist of primary amines on the surface and tertiary amines in the interior. The transfection activity of the dendrimers is dramatically enhanced (> 50-fold) by heat treatment in a variety of solvolytic solvents, e.g., water or butanol. Such treatment induces significant degradation of the dendrimer at the amide linkage, resulting in a… CONTINUE READING


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