In vitro functional testing of endothelial progenitor cells that overexpress thrombomodulin.

@article{Stroncek2011InVF,
  title={In vitro functional testing of endothelial progenitor cells that overexpress thrombomodulin.},
  author={John D Stroncek and Yujing Xue and Nabila Haque and Jeffrey Harold Lawson and William Monty Reichert},
  journal={Tissue engineering. Part A},
  year={2011},
  volume={17 15-16},
  pages={2091-100}
}
This study investigated the augmentation of endothelial progenitor cell (EPC) thromboresistance by using gene therapy to overexpress thrombomodulin (TM), an endothelial cell membrane glycoprotein that has potent anti-coagulant properties. Late outgrowth EPCs were isolated from peripheral blood of patients with documented coronary artery disease and transfected with an adenoviral vector containing human TM. EPC transfection conditions for maximizing TM expression, transfection efficiency, and… CONTINUE READING

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