In vitro function of islets of Langerhans encapsulated with a membrane of porcine chondrocytes for immunoisolation.

Abstract

BACKGROUND/AIMS Widespread clinical application of islet transplantation remains restricted, because of insufficient methods to prevent rejection and autoimmune destruction of islet grafts. In this study we demonstrate long-term function of islets of Langerhans within a capsule of porcine chondrocytes which may serve as an immunoisolation barrier utilizing… (More)

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