In vitro expression of major histocompatibility class I and class II antigens by conditionally immortalized murine neural stem cells.

The expression of major histocompatibility complex (MHC) antigens on the surface of cells is intimately linked to in vivo graft survival. It has been previously shown that the conditionally immortalized temperature-sensitive Maudsley hippocampal clone 36 (MHP36) neural stem cells show good long-term graft survival and do not elicit an acute immunological… CONTINUE READING